|Other Names||DNA dC->dU-editing enzyme APOBEC-3C, A3C, 354-, APOBEC1-like, Phorbolin I, APOBEC3C, APOBEC1L, PBI|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double- stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.|
|Cellular Location||Nucleus. Cytoplasm.|
|Tissue Location||Expressed in spleen, testes, peripherical blood lymphocytes, heart, thymus, prostate and ovary|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the cytidine deaminase genefamily. It is one of seven related genes or pseudogenes found in acluster thought to result from gene duplication, on chromosome 22.Members of the cluster encode proteins that are structurally andfunctionally related to the C to U RNA-editing cytidine deaminaseAPOBEC1. It is thought that the proteins may be RNA editing enzymesand have roles in growth or cell cycle control. [provided byRefSeq].
Albin, J.S., et al. Expert Rev Mol Med 12, E4 (2010) :Prochnow, C., et al. Sci. China, C, Life Sci. 52(10):893-902(2009)Lin, H., et al. Invest. Ophthalmol. Vis. Sci. 50(9):4436-4443(2009)Stauch, B., et al. Proc. Natl. Acad. Sci. U.S.A. 106(29):12079-12084(2009)Ross, S.R. PLoS Pathog. 5 (4), E1000347 (2009) :
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.