|Other Names||DNA dC->dU-editing enzyme APOBEC-3C, A3C, 354-, APOBEC1-like, Phorbolin I, APOBEC3C, APOBEC1L, PBI|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double- stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.|
|Cellular Location||Nucleus. Cytoplasm.|
|Tissue Location||Expressed in spleen, testes, peripherical blood lymphocytes, heart, thymus, prostate and ovary|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the cytidine deaminase genefamily. It is one of seven related genes or pseudogenes found in acluster thought to result from gene duplication, on chromosome 22.Members of the cluster encode proteins that are structurally andfunctionally related to the C to U RNA-editing cytidine deaminaseAPOBEC1. It is thought that the proteins may be RNA editing enzymesand have roles in growth or cell cycle control. [provided byRefSeq].
Albin, J.S., et al. Expert Rev Mol Med 12, E4 (2010) :Prochnow, C., et al. Sci. China, C, Life Sci. 52(10):893-902(2009)Lin, H., et al. Invest. Ophthalmol. Vis. Sci. 50(9):4436-4443(2009)Stauch, B., et al. Proc. Natl. Acad. Sci. U.S.A. 106(29):12079-12084(2009)Ross, S.R. PLoS Pathog. 5 (4), E1000347 (2009) :
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