|Other Names||Dynein light chain roadblock-type 2, Dynein light chain 2B, cytoplasmic, Roadblock domain-containing protein 2, DYNLRB2, DNCL2B, DNLC2B, ROBLD2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DNCL2B, DNLC2B, ROBLD2|
|Function||Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.|
|Cellular Location||Cytoplasm, cytoskeleton.|
|Tissue Location||High expression in heart, brain, placenta, skeletal muscle, prostate and small intestine; moderate in kidney, pancreas, spleen, testis, ovary and colon; low in lung, liver, thymus and leukocyte|
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Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Dastani, Z., et al. Eur. J. Hum. Genet. 18(3):342-347(2010)Jin, Q., et al. J. Cell. Physiol. 221(3):707-715(2009)Meyre, D., et al. Nat. Genet. 41(2):157-159(2009)Pfister, K.K., et al. J. Cell Biol. 171(3):411-413(2005)
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