|Other Names||Leucine zipper protein 4, Cancer/testis antigen 28, CT-28, CT28, Tumor antigen HOM-TES-85, LUZP4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Export adapter involved in mRNA nuclear export in cancer cells. Binds and enhances the RNA-binding activity of the nuclear RNA export factor NXF1. Can restore mRNA export function in cells compromised by loss of mRNA export adapters (PubMed:25662211).|
|Cellular Location||Nucleus. Cytoplasm. Note=In nuclear speckles Relocalizes to the cytoplasm during cell division|
|Tissue Location||Expressed specifically in testis. Also expressed in a wide variety of cancer types, but particularly high levels of expression observed in melanoma cells EMBL; AF124430; AAF28870.1; -; mRNA EMBL; AK093369; BAG52698.1; -; mRNA EMBL; AL109751; CAC09922.1; -; Genomic_DNA EMBL; BC128134; AAI28135.1; -; mRNA CCDS; CCDS14567.1; -. [Q9P127-1] RefSeq; NP_001305769.1; NM_001318840.1. [Q9P127-2] RefSeq; NP_057467.1; NM_016383.4. [Q9P127-1] UniGene; Hs.242183; - ProteinModelPortal; Q9P127; - BioGrid; 119383; 91 IntAct; Q9P127; 20 STRING; 9606.ENSP00000360988; - iPTMnet; Q9P127; - PhosphoSitePlus; Q9P127; - BioMuta; LUZP4; - DMDM; 74753106; - PaxDb; Q9P127; - PeptideAtlas; Q9P127; - PRIDE; Q9P127; - ProteomicsDB; 83637; - Ensembl; ENST00000371920; ENSP00000360988; ENSG00000102021. [Q9P127-1] GeneID; 51213; - KEGG; hsa:51213; - UCSC; uc004eqa.4; human. [Q9P127-1] CTD; 51213; - DisGeNET; 51213; - EuPathDB; HostDB:ENSG00000102021.10; - GeneCards; LUZP4; - HGNC; HGNC:24971; LUZP4 HPA; HPA046436; - HPA; HPA051999; - MIM; 300616; gene neXtProt; NX_Q9P127; - OpenTargets; ENSG00000102021; - PharmGKB; PA134920076; - eggNOG; ENOG410IY7Q; Eukaryota eggNOG; ENOG410Z9DE; LUCA GeneTree; ENSGT00390000002455; - HOGENOM; HOG000065721; - HOVERGEN; HBG101724; - InParanoid; Q9P127; - OMA; SERSHGH; - OrthoDB; EOG091G0QN2; - PhylomeDB; Q9P127; - TreeFam; TF350091; - Reactome; R-HSA-109688; Cleavage of Growing Transcript in the Termination Region Reactome; R-HSA-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript Reactome; R-HSA-72187; mRNA 3'-end processing GenomeRNAi; 51213; - PRO; PR:Q9P127; - Proteomes; UP000005640; Chromosome X Bgee; ENSG00000102021; - CleanEx; HS_LUZP4; - ExpressionAtlas; Q9P127; baseline and differential Genevisible; Q9P127; HS GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW 1: Evidence at protein level; Alternative splicing; Complete proteome; Cytoplasm; mRNA transport; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; RNA-binding; Transport CHAIN 1 313 Leucine zipper protein 4 /FTId=PRO_0000288649 REGION 1 119 Interaction with DDX39B/UAP56 REGION 51 80 Arg-rich; required for RNA-binding REGION 178 236 RS-containing His-rich (RS-H); necessary for nuclear localization REGION 238 287 Leucine-zipper; required for RNA-binding and for its relocalization to the cytoplasm during cell division REGION 241 313 Interaction with NXF1 MOTIF 22 40 UAP56-binding motif (UBM); required for proper nuclear localization MOD_RES 234 234 Phosphoserine VAR_SEQ 1 32 MASFRKLTLSEKVPPNHPSRKKVNFLDMSLDD -> MLKKK RIKDRTIVKRNRLQDSNQKLIDIAIGE (in isoform 2). /FTId=VSP_053926 VAR_SEQ 33 114 Missing (in isoform 2) /FTId=VSP_053927 VARIANT 14 14 P -> S (in dbSNP:rs10482480) /FTId=VAR_051146 VARIANT 306 306 T -> A (in dbSNP:rs35314601) /FTId=VAR_051147 SEQUENCE 313 AA; 35937 MW; E041911D9BA1DC8B CRC64; MASFRKLTLS EKVPPNHPSR KKVNFLDMSL DDIIIYKELE GTNAEEEKNK RQNHSKKESP SRQQSKAHRH RHRRGYSRCR SNSEEGNHDK KPSQKPSGFK SGQHPLNGQP LIEQEKCSDN YEAQAEKNQG QSEGNQHQSE GNPDKSEESQ GQPEENHHSE RSRNHLERSL SQSDRSQGQL KRHHPQYERS HGQYKRSHGQ SERSHGHSER SHGHSERSHG HSERSHGHSK RSRSQGDLVD TQSDLIATQR DLIATQKDLI ATQRDLIATQ RDLIVTQRDL VATERDLINQ SGRSHGQSER HQRYSTGKNT ITT|
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Tureci, O., et al. Oncogene 21(24):3879-3888(2002)Sahin, U., et al. Clin. Cancer Res. 6(10):3916-3922(2000)
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