|Other Names||Leucine zipper protein 4, Cancer/testis antigen 28, CT-28, CT28, Tumor antigen HOM-TES-85, LUZP4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Export adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Binds NXF1, enhances its RNA-binding activity and is required for its localization to the nuclear rim. Associates with the TREX complex via its interaction with the TREX components THOC1, THOC5 and DDX39B/UAP56. Capable of complementing knockdown of ALYREF/THOC4 and partially complementing a double ALYREF/UIF knockdown in vivo. Required for the growth of the melanoma cell line MeWo (PubMed:25662211).|
|Cellular Location||Nucleus. Cytoplasm. Note=In nuclear speckles Relocalizes to the cytoplasm during cell division|
|Tissue Location||Expressed specifically in testis. Also expressed in a wide variety of cancer types, but particularly high levels of expression observed in melanoma cells EMBL; AF124430; AAF28870.1; -; mRNA EMBL; AK093369; BAG52698.1; -; mRNA EMBL; AL109751; CAC09922.1; -; Genomic_DNA EMBL; BC128134; AAI28135.1; -; mRNA CCDS; CCDS14567.1; -. [Q9P127-1] RefSeq; NP_001305769.1; NM_001318840.1. [Q9P127-2] RefSeq; NP_057467.1; NM_016383.4. [Q9P127-1] UniGene; Hs.242183; - ProteinModelPortal; Q9P127; - BioGrid; 119383; 91 IntAct; Q9P127; 17 STRING; 9606.ENSP00000360988; - iPTMnet; Q9P127; - PhosphoSitePlus; Q9P127; - BioMuta; LUZP4; - DMDM; 74753106; - PaxDb; Q9P127; - PeptideAtlas; Q9P127; - PRIDE; Q9P127; - Ensembl; ENST00000371920; ENSP00000360988; ENSG00000102021. [Q9P127-1] GeneID; 51213; - KEGG; hsa:51213; - UCSC; uc004eqa.4; human. [Q9P127-1] CTD; 51213; - DisGeNET; 51213; - GeneCards; LUZP4; - HGNC; HGNC:24971; LUZP4 HPA; HPA046436; - HPA; HPA051999; - MIM; 300616; gene neXtProt; NX_Q9P127; - OpenTargets; ENSG00000102021; - PharmGKB; PA134920076; - eggNOG; ENOG410IY7Q; Eukaryota eggNOG; ENOG410Z9DE; LUCA GeneTree; ENSGT00390000002455; - HOGENOM; HOG000065721; - HOVERGEN; HBG101724; - InParanoid; Q9P127; - OMA; SERSHGH; - OrthoDB; EOG091G0QN2; - PhylomeDB; Q9P127; - TreeFam; TF350091; - BioCyc; ZFISH:ENSG00000102021-MONOMER; - Reactome; R-HSA-109688; Cleavage of Growing Transcript in the Termination Region Reactome; R-HSA-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript Reactome; R-HSA-72187; mRNA 3'-end processing GenomeRNAi; 51213; - PRO; PR:Q9P127; - Proteomes; UP000005640; Chromosome X Bgee; ENSG00000102021; - CleanEx; HS_LUZP4; - ExpressionAtlas; Q9P127; baseline and differential Genevisible; Q9P127; HS GO; GO:0005737; C:cytoplasm; IDA:UniProtKB GO; GO:0005634; C:nucleus; IDA:UniProtKB GO; GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB GO; GO:0003697; F:single-stranded DNA binding; IDA:UniProtKB GO; GO:0003727; F:single-stranded RNA binding; IDA:UniProtKB GO; GO:0016049; P:cell growth; IMP:UniProtKB GO; GO:0006406; P:mRNA export from nucleus; IMP:UniProtKB 1: Evidence at protein level; Alternative splicing; Complete proteome; Cytoplasm; mRNA transport; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; RNA-binding; Transport CHAIN 1 313 Leucine zipper protein 4 /FTId=PRO_0000288649 REGION 1 119 Interaction with DDX39B/UAP56 REGION 51 80 Arg-rich; required for RNA-binding REGION 178 236 RS-containing His-rich (RS-H); necessary for nuclear localization REGION 238 287 Leucine-zipper; required for RNA-binding and for its relocalization to the cytoplasm during cell division REGION 241 313 Interaction with NXF1 MOTIF 22 40 UAP56-binding motif (UBM); required for proper nuclear localization MOD_RES 234 234 Phosphoserine VAR_SEQ 1 32 MASFRKLTLSEKVPPNHPSRKKVNFLDMSLDD -> MLKKK RIKDRTIVKRNRLQDSNQKLIDIAIGE (in isoform 2). /FTId=VSP_053926 VAR_SEQ 33 114 Missing (in isoform 2) /FTId=VSP_053927 VARIANT 14 14 P -> S (in dbSNP:rs10482480) /FTId=VAR_051146 VARIANT 306 306 T -> A (in dbSNP:rs35314601) /FTId=VAR_051147 SEQUENCE 313 AA; 35937 MW; E041911D9BA1DC8B CRC64; MASFRKLTLS EKVPPNHPSR KKVNFLDMSL DDIIIYKELE GTNAEEEKNK RQNHSKKESP SRQQSKAHRH RHRRGYSRCR SNSEEGNHDK KPSQKPSGFK SGQHPLNGQP LIEQEKCSDN YEAQAEKNQG QSEGNQHQSE GNPDKSEESQ GQPEENHHSE RSRNHLERSL SQSDRSQGQL KRHHPQYERS HGQYKRSHGQ SERSHGHSER SHGHSERSHG HSERSHGHSK RSRSQGDLVD TQSDLIATQR DLIATQKDLI ATQRDLIATQ RDLIVTQRDL VATERDLINQ SGRSHGQSER HQRYSTGKNT ITT|
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Provided below are standard protocols that you may find useful for product applications.
Tureci, O., et al. Oncogene 21(24):3879-3888(2002)Sahin, U., et al. Clin. Cancer Res. 6(10):3916-3922(2000)
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