|Other Names||Lipase member I, LIPI, 311-, Cancer/testis antigen 17, CT17, LPD lipase, Membrane-associated phosphatidic acid-selective phospholipase A1-beta, mPA-PLA1 beta, LIPI, LPDL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).|
|Cellular Location||Isoform 1: Membrane. Secreted. Note=May associate with lipid draft|
|Tissue Location||Expressed in testis. Expressed exclusively at the connecting piece of the sperm.|
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The protein encoded by this gene is a phospholipase thathydrolyzes phosphatidic acid to produce lysophosphatidic acid. Theencoded protein, which can be inhibited by sodium vanadate, may befound exclusively in sperm. Defects in this gene are a cause ofsusceptibility to familial hypertrigliceridemia. [provided byRefSeq].
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Hiramatsu, T., et al. J. Biol. Chem. 278(49):49438-49447(2003)Wen, X.Y., et al. Hum. Mol. Genet. 12(10):1131-1143(2003)
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