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FBXW12 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q6X9E4
Other Accession NP_001153399.1, NP_001153401.1, NP_996985.2
Clone Names 100107027
Peptide ID 100107027
Additional Information
Other Names F-box/WD repeat-containing protein 12, F-box and WD-40 domain-containing protein 12, F-box only protein 35, FBXW12, FBW12, FBXO12, FBXO35
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FBXW12
Synonyms FBW12, FBXO12, FBXO35
Function Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex.
Tissue Location Ubiquitously expressed. EMBL; AY247969; AAP75562.1; -; mRNA EMBL; AC104448; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC101304; AAI01305.1; -; mRNA EMBL; BC101305; AAI01306.1; -; mRNA CCDS; CCDS2764.1; -. [Q6X9E4-1] CCDS; CCDS54577.1; -. [Q6X9E4-3] CCDS; CCDS54578.1; -. [Q6X9E4-2] RefSeq; NP_001153399.1; NM_001159927.1. [Q6X9E4-2] RefSeq; NP_001153401.1; NM_001159929.1. [Q6X9E4-3] RefSeq; NP_996985.2; NM_207102.2. [Q6X9E4-1] RefSeq; XP_016861713.1; XM_017006224.1. [Q6X9E4-1] UniGene; Hs.288793; - ProteinModelPortal; Q6X9E4; - BioGrid; 130052; 9 STRING; 9606.ENSP00000296438; - iPTMnet; Q6X9E4; - PhosphoSitePlus; Q6X9E4; - BioMuta; FBXW12; - DMDM; 215273983; - PaxDb; Q6X9E4; - PeptideAtlas; Q6X9E4; - PRIDE; Q6X9E4; - ProteomicsDB; 67792; - ProteomicsDB; 67793; -. [Q6X9E4-2] Ensembl; ENST00000296438; ENSP00000296438; ENSG00000164049. [Q6X9E4-1] Ensembl; ENST00000415155; ENSP00000414683; ENSG00000164049. [Q6X9E4-2] Ensembl; ENST00000445170; ENSP00000406139; ENSG00000164049. [Q6X9E4-3] GeneID; 285231; - KEGG; hsa:285231; - UCSC; uc003csr.3; human. [Q6X9E4-1] CTD; 285231; - EuPathDB; HostDB:ENSG00000164049.14; - GeneCards; FBXW12; - H-InvDB; HIX0019770; - HGNC; HGNC:20729; FBXW12 HPA; HPA037491; - HPA; HPA037492; - MIM; 609075; gene neXtProt; NX_Q6X9E4; - OpenTargets; ENSG00000164049; - PharmGKB; PA134980842; - eggNOG; ENOG410IHPA; Eukaryota eggNOG; ENOG4111ZD7; LUCA GeneTree; ENSGT00390000007158; - HOGENOM; HOG000112541; - HOVERGEN; HBG051564; - InParanoid; Q6X9E4; - KO; K10267; - OMA; KVWNCQD; - OrthoDB; EOG091G0619; - PhylomeDB; Q6X9E4; - TreeFam; TF332550; - Reactome; R-HSA-8951664; Neddylation Reactome; R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation ChiTaRS; FBXW12; human GenomeRNAi; 285231; - PRO; PR:Q6X9E4; - Proteomes; UP000005640; Chromosome 3 Bgee; ENSG00000164049; - CleanEx; HS_FBXW12; - ExpressionAtlas; Q6X9E4; baseline and differential GO; GO:0005829; C:cytosol; TAS:Reactome GO; GO:0004842; F:ubiquitin-protein transferase activity; EXP:Reactome GO; GO:0043687; P:post-translational protein modification; TAS:Reactome GO; GO:0000209; P:protein polyubiquitination; TAS:Reactome Gene3D; 2.130.10.10; -; 1 InterPro; IPR036047; F-box-like_dom_sf InterPro; IPR001810; F-box_dom InterPro; IPR011044; Quino_amine_DH_bsu InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf Pfam; PF12937; F-box-like; 1 SMART; SM00256; FBOX; 1 SUPFAM; SSF50969; SSF50969; 3 SUPFAM; SSF81383; SSF81383; 1 PROSITE; PS50181; FBOX; 1 2: Evidence at transcript level; Alternative splicing; Complete proteome; Polymorphism; Reference proteome; Repeat; Ubl conjugation pathway; WD repeat CHAIN 1 464 F-box/WD repeat-containing protein 12 /FTId=PRO_0000051000 DOMAIN 1 45 F-box. {ECO:0000255|PROSITE- ProRule:PRU00080} REPEAT 89 132 WD 1 REPEAT 136 174 WD 2 REPEAT 178 217 WD 3 REPEAT 222 263 WD 4 REPEAT 270 315 WD 5 REPEAT 320 367 WD 6 REPEAT 370 407 WD 7 REPEAT 416 461 WD 8 VAR_SEQ 1 29 MEIRLPDLALKRIFSFLDLFGLLQVSQVN -> MSPTHQIQ DP (in isoform 3) /FTId=VSP_044601 VAR_SEQ 136 205 Missing (in isoform 2) /FTId=VSP_042911 VARIANT 6 6 P -> L (in dbSNP:rs17080138) /FTId=VAR_057601 VARIANT 166 166 R -> W (in dbSNP:rs6442117) /FTId=VAR_057602 VARIANT 273 273 V -> D (in dbSNP:rs6784322) /FTId=VAR_057603 CONFLICT 278 278 F -> L (in Ref. 3; AAI01306) CONFLICT 317 317 T -> P (in Ref. 1; AAP75562) SEQUENCE 464 AA; 53056 MW; DFF81F0D718CEF7B CRC64; MEIRLPDLAL KRIFSFLDLF GLLQVSQVNK HWNRIADSDY LWRSLSLQRW DCSNFTNQHL GTHTWKQFFL HQRRKELRLA LAQPHNFIYK VTKNIAFETE LAYLSGNRLT VDEQEKSIIC SVSPKQELCA WDVQEGTMIW SSPVQEFHFS NLVTLPQMHL AITMDRKKTI KVWNCQDRDA LAVLPMPQPC YCMEAYLTKD GPFLMVGDAA GDIYTFTLPG LRDVSKVTAF QYGIVLLHCS PDKKWVFACG TYSRTLPQVF LTESLLRPSE GSVPLSTFLP HKLCASACWT PKVKNRITLM SQSSTGKKTE FITFDLTTKK TGGQTVIQAY EIASFQVAAH LKCPIWMGAS DGYMIVFTSG PYLLLFSITG FLLQRFEDHQ AAINNFWVDP CYVLTTSENS VHVYMWEEGG RHPYLRSCCH LENTWHDHTT DSCISSVMCD NASIVLRVRK VSDSSILVMY SLNT
Research Areas
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Background

Members of the F-box protein family, such as FBXW12, arecharacterized by an approximately 40-amino acid F-box motif. SCFcomplexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM603034), and F-box proteins, act as protein-ubiquitin ligases.F-box proteins interact with SKP1 through the F box, and theyinteract with ubiquitination targets through other proteininteraction domains (Jin et al., 2004 [PubMed 15520277]).[suppliedby OMIM].

References

Jin, J., et al. Genes Dev. 18(21):2573-2580(2004)Zeng, L., et al. Mol. Biol. Rep. 31(1):51-57(2004)

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$ 80.00
Cat# BP10268b
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