HCM (RNMT) Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O43148 |
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Clone Names | 70411216 |
Gene ID | 8731 |
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Other Names | mRNA cap guanine-N7 methyltransferase, RG7MT1, mRNA (guanine-N(7)-)-methyltransferase, mRNA cap methyltransferase, hCMT1, hMet, hcm1p, RNMT, KIAA0398 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP1026a was selected from the N-term region of human RNMT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | RNMT |
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Synonyms | KIAA0398 |
Function | Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:9790902, PubMed:9705270, PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871). Binds RNA containing 5'-terminal GpppC (PubMed:11114884). |
Cellular Location | Nucleus |
Tissue Location | Widely expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
RNMT is an mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. This protein binds RNA containing 5'-terminal GpppC.
References
Tsukamoto T., Biochem. Biophys. Res. Commun. 251:27-34(1998).Pillutla R.C., J. Biol. Chem. 273:21443-21446(1998).
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