|Other Names||mRNA cap guanine-N7 methyltransferase, RG7MT1, mRNA (guanine-N(7)-)-methyltransferase, mRNA cap methyltransferase, hCMT1, hMet, hcm1p, RNMT, KIAA0398|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1026a was selected from the N-term region of human RNMT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMMET complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:9790902, PubMed:9705270, PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871). Binds RNA containing 5'-terminal GpppC (PubMed:11114884).|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
RNMT is an mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. This protein binds RNA containing 5'-terminal GpppC.
Tsukamoto T., Biochem. Biophys. Res. Commun. 251:27-34(1998).Pillutla R.C., J. Biol. Chem. 273:21443-21446(1998).
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