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TFAM Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q00059 |
|---|---|
| Other Accession | NP_003192.1 |
| Clone Names | 90713251 |
| Gene ID | 7019 |
|---|---|
| Other Names | Transcription factor A, mitochondrial, mtTFA, Mitochondrial transcription factor 1, MtTF1, Transcription factor 6, TCF-6, Transcription factor 6-like 2, TFAM, TCF6, TCF6L2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TFAM (HGNC:11741) |
|---|---|
| Synonyms | TCF6, TCF6L2 |
| Function | Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (PubMed:29445193, PubMed:32183942). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:20410300). Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase (PubMed:22037172). Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites (PubMed:22037172). Is able to unwind DNA (PubMed:22037172). Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes (PubMed:1737790). Required for maintenance of normal levels of mitochondrial DNA (PubMed:22841477, PubMed:19304746). May play a role in organizing and compacting mitochondrial DNA (PubMed:22037171). |
| Cellular Location | Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a mitochondrial transcription factorthat is a key activator of mitochondrial transcription as well as aparticipant in mitochondrial genome replication. Studies in micehave demonstrated that this gene product is required to regulatethe mitochondrial genome copy number and is essential for embryonicdevelopment. A mouse model for Kearns-Sayre syndrome was producedwhen expression of this gene was eliminated by targeted disruptionin heart and muscle cells.
References
Wang, W., et al. Nucleic Acids Res. (2010) In press :Corneveaux, J.J., et al. Hum. Mol. Genet. 19(16):3295-3301(2010)Akhmetov, I.I., et al. Fiziol Cheloveka 36(2):121-125(2010)Shulman, J.M., et al. PLoS ONE 5 (6), E11244 (2010) :Laumet, G., et al. J. Alzheimers Dis. 20(4):1181-1188(2010)
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