|Other Accession||NP_005566.2, NP_787116.2|
|Other Names||Leucyl-cystinyl aminopeptidase, Cystinyl aminopeptidase, Insulin-regulated membrane aminopeptidase, Insulin-responsive aminopeptidase, IRAP, Oxytocinase, OTase, Placental leucine aminopeptidase, P-LAP, Leucyl-cystinyl aminopeptidase, pregnancy serum form, LNPEP, OTASE|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein. Note=In brain only the membrane- bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases|
|Tissue Location||Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon|
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This gene encodes a zinc-dependent aminopeptidase thatcleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin,dynorphin A and other peptide hormones. The protein can be secretedin maternal serum, reside in intracellular vesicles with theinsulin-responsive glucose transporter GLUT4, or form a type IIintegral membrane glycoprotein. The protein catalyzes the finalstep in the conversion of angiotensinogen to angiotensin IV (AT4)and is also a receptor for AT4. Alternative splicing results inmultiple transcript variants encoding different isoforms. [providedby RefSeq].
Georgiadou, D., et al. J. Immunol. 185(3):1584-1592(2010)Williams, P.J., et al. Placenta 31(5):448-455(2010)Landau, R., et al. Neuro Endocrinol. Lett. 31(1):63-66(2010)Johnson, M.P., et al. Hum. Genet. 126(5):655-666(2009)Saveanu, L., et al. Science 325(5937):213-217(2009)
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