|Other Accession||NP_005566.2, NP_787116.2|
|Other Names||Leucyl-cystinyl aminopeptidase, Cystinyl aminopeptidase, Insulin-regulated membrane aminopeptidase, Insulin-responsive aminopeptidase, IRAP, Oxytocinase, OTase, Placental leucine aminopeptidase, P-LAP, Leucyl-cystinyl aminopeptidase, pregnancy serum form, LNPEP, OTASE|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein. Note=In brain only the membrane- bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases|
|Tissue Location||Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a zinc-dependent aminopeptidase thatcleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin,dynorphin A and other peptide hormones. The protein can be secretedin maternal serum, reside in intracellular vesicles with theinsulin-responsive glucose transporter GLUT4, or form a type IIintegral membrane glycoprotein. The protein catalyzes the finalstep in the conversion of angiotensinogen to angiotensin IV (AT4)and is also a receptor for AT4. Alternative splicing results inmultiple transcript variants encoding different isoforms. [providedby RefSeq].
Georgiadou, D., et al. J. Immunol. 185(3):1584-1592(2010)Williams, P.J., et al. Placenta 31(5):448-455(2010)Landau, R., et al. Neuro Endocrinol. Lett. 31(1):63-66(2010)Johnson, M.P., et al. Hum. Genet. 126(5):655-666(2009)Saveanu, L., et al. Science 325(5937):213-217(2009)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.