LNPEP Antibody (N-Term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UIQ6 |
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Other Accession | NP_005566.2, NP_787116.2 |
Clone Names | 91023019 |
Gene ID | 4012 |
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Other Names | Leucyl-cystinyl aminopeptidase, Cystinyl aminopeptidase, Insulin-regulated membrane aminopeptidase, Insulin-responsive aminopeptidase, IRAP, Oxytocinase, OTase, Placental leucine aminopeptidase, P-LAP, Leucyl-cystinyl aminopeptidase, pregnancy serum form, LNPEP, OTASE |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | LNPEP |
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Synonyms | OTASE |
Function | Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. |
Cellular Location | Cell membrane; Single-pass type II membrane protein Note=In brain only the membrane-bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases |
Tissue Location | Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a zinc-dependent aminopeptidase thatcleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin,dynorphin A and other peptide hormones. The protein can be secretedin maternal serum, reside in intracellular vesicles with theinsulin-responsive glucose transporter GLUT4, or form a type IIintegral membrane glycoprotein. The protein catalyzes the finalstep in the conversion of angiotensinogen to angiotensin IV (AT4)and is also a receptor for AT4. Alternative splicing results inmultiple transcript variants encoding different isoforms. [providedby RefSeq].
References
Georgiadou, D., et al. J. Immunol. 185(3):1584-1592(2010)Williams, P.J., et al. Placenta 31(5):448-455(2010)Landau, R., et al. Neuro Endocrinol. Lett. 31(1):63-66(2010)Johnson, M.P., et al. Hum. Genet. 126(5):655-666(2009)Saveanu, L., et al. Science 325(5937):213-217(2009)
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