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SLC25A12 Antibody (N-Term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O75746 |
|---|---|
| Other Accession | NP_003696.2 |
| Clone Names | 91023023 |
| Gene ID | 8604 |
|---|---|
| Other Names | Calcium-binding mitochondrial carrier protein Aralar1, Mitochondrial aspartate glutamate carrier 1, Solute carrier family 25 member 12, SLC25A12, ARALAR1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC25A12 (HGNC:10982) |
|---|---|
| Function | Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (PubMed:11566871, PubMed:19641205, PubMed:24515575). Also mediates the uptake of L-cysteinesulfinate by mitochondria in exchange of L- glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (PubMed:11566871). |
| Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein |
| Tissue Location | Expressed predominantly in the heart and skeletal muscle, weakly in brain and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a calcium-binding mitochondrial carrierprotein. The encoded protein localizes to the mitochondria and isinvolved in the exchange of aspartate for glutamate across theinner mitochondrial membrane. Polymorphisms in the gene encodingthis protein may be associated with risk of autism. [provided byRefSeq].
References
Maestrini, E., et al. Mol. Psychiatry 15(9):954-968(2010)Chien, W.H., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry 34(1):189-192(2010)Chakrabarti, B., et al. Autism Res 2(3):157-177(2009)Marmol, P., et al. J. Biol. Chem. 284(1):515-524(2009)Turunen, J.A., et al. Autism Res 1(3):189-192(2008)
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