|Other Names||Calcium-binding mitochondrial carrier protein Aralar1, Mitochondrial aspartate glutamate carrier 1, Solute carrier family 25 member 12, SLC25A12, ARALAR1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane (PubMed:11566871, PubMed:25410934). May have a function in the urea cycle (PubMed:11566871).|
|Cellular Location||Mitochondrion inner membrane; Multi-pass membrane protein|
|Tissue Location||Expressed predominantly in the heart and skeletal muscle, weakly in brain and kidney|
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This gene encodes a calcium-binding mitochondrial carrierprotein. The encoded protein localizes to the mitochondria and isinvolved in the exchange of aspartate for glutamate across theinner mitochondrial membrane. Polymorphisms in the gene encodingthis protein may be associated with risk of autism. [provided byRefSeq].
Maestrini, E., et al. Mol. Psychiatry 15(9):954-968(2010)Chien, W.H., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry 34(1):189-192(2010)Chakrabarti, B., et al. Autism Res 2(3):157-177(2009)Marmol, P., et al. J. Biol. Chem. 284(1):515-524(2009)Turunen, J.A., et al. Autism Res 1(3):189-192(2008)
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