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U2AF4 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8WU68
Other Accession NP_659424.2, NP_001035515.1
Clone Names 91113184
Peptide ID 91113184
Additional Information
Gene ID 199746
Other Names Splicing factor U2AF 26 kDa subunit, U2 auxiliary factor 26, U2 small nuclear RNA auxiliary factor 1-like protein 4, U2AF1-like 4, U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3, U2 small nuclear RNA auxiliary factor 1-like protein 3, U2AF1-like protein 3, U2AF1L4, U2AF1-RS3, U2AF1L3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name U2AF1L4
Synonyms U2AF1-RS3, U2AF1L3
Function RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity).
Cellular Location Nucleus {ECO:0000250|UniProtKB:Q8BGJ9}. Nucleus speckle {ECO:0000250|UniProtKB:Q8BGJ9}. Cytoplasm {ECO:0000250|UniProtKB:Q8BGJ9}. Note=Interaction with C1QBP is required for the nuclear translocation. Displays active nucleo- cytoplasmic shuttling. {ECO:0000250|UniProtKB:Q8BGJ9}
Tissue Location Isoform 2 is widely expressed. Isoform 3 is highly expressed in heart, brain and lung, lower expressed in thymus and much lower expressed in peripheral blood leukocytes
Research Areas
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References

Heyd, F., et al. J. Biol. Chem. 283(28):19636-19645(2008)Dou, T., et al. DNA Seq. 16(3):230-234(2005)Shepard, J., et al. Mol. Cell. Biol. 22(1):221-230(2002)Pearsall, R.S., et al. Biochem. Biophys. Res. Commun. 222(1):171-177(1996)Kitagawa, K., et al. Genomics 30(2):257-263(1995)

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$ 80.00
Cat# BP10274a
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