U2AF4 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8WU68 |
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Other Accession | NP_659424.2, NP_001035515.1 |
Clone Names | 91113184 |
Gene ID | 199746 |
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Other Names | Splicing factor U2AF 26 kDa subunit, U2 auxiliary factor 26, U2 small nuclear RNA auxiliary factor 1-like protein 4, U2AF1-like 4, U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3, U2 small nuclear RNA auxiliary factor 1-like protein 3, U2AF1-like protein 3, U2AF1L4, U2AF1-RS3, U2AF1L3 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | U2AF1L4 |
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Synonyms | U2AF1-RS3, U2AF1L3 |
Function | RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity). |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q8BGJ9}. Nucleus speckle {ECO:0000250|UniProtKB:Q8BGJ9}. Cytoplasm {ECO:0000250|UniProtKB:Q8BGJ9}. Note=Interaction with C1QBP is required for the nuclear translocation. Displays active nucleo-cytoplasmic shuttling. {ECO:0000250|UniProtKB:Q8BGJ9} |
Tissue Location | Isoform 2 is widely expressed. Isoform 3 is highly expressed in heart, brain and lung, lower expressed in thymus and much lower expressed in peripheral blood leukocytes |
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Provided below are standard protocols that you may find useful for product applications.
References
Heyd, F., et al. J. Biol. Chem. 283(28):19636-19645(2008)Dou, T., et al. DNA Seq. 16(3):230-234(2005)Shepard, J., et al. Mol. Cell. Biol. 22(1):221-230(2002)Pearsall, R.S., et al. Biochem. Biophys. Res. Commun. 222(1):171-177(1996)Kitagawa, K., et al. Genomics 30(2):257-263(1995)
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