|Other Accession||NP_061824.3, NP_714926.1|
|Other Names||Homeobox protein Hox-A10, Homeobox protein Hox-18, Homeobox protein Hox-1H, PL, HOXA10, HOX1H|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'.|
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In vertebrates, the genes encoding the class oftranscription factors called homeobox genes are found in clustersnamed A, B, C, and D on four separate chromosomes. Expression ofthese proteins is spatially and temporally regulated duringembryonic development. This gene is part of the A cluster onchromosome 7 and encodes a DNA-binding transcription factor thatmay regulate gene expression, morphogenesis, and differentiation.More specifically, it may function in fertility, embryo viability,and regulation of hematopoietic lineage commitment. Alternativelyspliced transcript variants encoding different isoforms have beendescribed.
Du, H., et al. Biol. Reprod. 83(2):205-211(2010)Cheng, W., et al. J. Cancer Res. Clin. Oncol. 136(8):1221-1227(2010)Liatsikos, S.A., et al. Reprod. Biomed. Online 21(1):126-132(2010)Godbole, G., et al. J. Reprod. Immunol. 85(2):130-139(2010)Ko, S.Y., et al. Mol. Cell. Endocrinol. 317 (1-2), 112-119 (2010) :
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