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ZRAB3 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q5FWF4
Other Accession NP_115519.2
Clone Names 91119117
Peptide ID 91119117
Additional Information
Gene ID 84083
Other Names DNA annealing helicase and endonuclease ZRANB3, Annealing helicase 2, AH2, Zinc finger Ran-binding domain-containing protein 3, DNA annealing helicase ZRANB3, 364-, Endonuclease ZRANB3, 31--, ZRANB3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZRANB3
Function DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.
Cellular Location Nucleus. Chromosome. Note=Following DNA damage, recruited to sites of DNA damage and stalled replication forks by polyubiquitinated PCNA
Research Areas
Citations (0)

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References

Rose, J. Phd, et al. Mol. Med. (2010) In press :

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$ 80.00
Cat# BP10285c
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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