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JMJD4 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession Q9H9V9
Additional Information
Gene ID 65094
Other Names JmjC domain-containing protein 4, Jumonji domain-containing protein 4, JMJD4
Target/Specificity The synthetic peptide sequence is selected from aa 438-455 of HUMAN JMJD4
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name JMJD4
Research Areas
Citations (0)

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Background

Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.

References

Ota, T., et al., Nat. Genet. 36(1):40-45 (2004).

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$ 80.00
$ 99.00
Cat# BP1030B
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