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JMJD5 Antibody (C-term 2) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8N371
Clone Names 6080539
Peptide ID 6080539
Additional Information
Gene ID 79831
Other Names Lysine-specific demethylase 8, JmjC domain-containing protein 5, Jumonji domain-containing protein 5, KDM8, JMJD5
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1031a was selected from the C-term region of human JMJD5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KDM8
Synonyms JMJD5
Function Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.
Cellular Location Nucleus.
Tissue Location Weakly expressed in most cells. Highly expressed in breast cancer cells.
Research Areas
Citations (0)

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Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.


Ota, T., et al., Nat. Genet. 36(1):40-45 (2004).

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$ 80.00
Cat# BP1031a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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