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SLC5A12 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q1EHB4
Other Accession NP_848593.2
Clone Names 100111097
Peptide ID 100111097
Additional Information
Gene ID 159963
Other Names Sodium-coupled monocarboxylate transporter 2, Electroneutral sodium monocarboxylate cotransporter, Low-affinity sodium-lactate cotransporter, Solute carrier family 5 member 12, SLC5A12, SMCT2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC5A12
Synonyms SMCT2
Function Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D- hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina (By similarity). Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate (By similarity).
Cellular Location Apical cell membrane; Multi-pass membrane protein. Note=Detected at the brush border membrane of the kidney. Colocalizes with viementin in Mueller cells (By similarity).
Research Areas
Citations (0)

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Normal blood lactate is maintained at about 1.5 mM, andlittle filtered lactate is excreted in urine. Reabsorption oflactate is mediated by the low-affinity Na(+)-coupled lactatetransporter SLC5A12 in the initial part of the proximal tubule andby the high-affinity Na(+)-coupled lactate transporter SLC5A8 (MIM608044) in the distal proximal tubule (Gopal et al., 2007 [PubMed17692818]).


Gopal, E., et al. Biochim. Biophys. Acta 1768(11):2690-2697(2007)

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$ 80.00
Cat# BP10330b
(40 western blots)
Availability: In Stock
Bulk Size
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