|Other Names||Platelet endothelial aggregation receptor 1, hPEAR1, Multiple epidermal growth factor-like domains protein 12, Multiple EGF-like domains protein 12, PEAR1, MEGF12|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells.|
|Cellular Location||Cell membrane; Single-pass membrane protein. Note=Detected on the cell surface in resting platelets.|
|Tissue Location||Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion, endothelial cells of umbilical cord artery and vein, megakaryocytes, osteoblasts, coronary muscle and erythroid cells. Weakly expressed in peripheral blood leukocytes and macrophages|
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Provided below are standard protocols that you may find useful for product applications.
PEAR1 is a platelet receptor that signals upon theformation of platelet-platelet contacts independent of plateletactivation and secondary to platelet aggregation (Nanda et al.,2005 [PubMed 15851471]).
Johnson, A.D., et al. Nat. Genet. 42(7):608-613(2010)Jones, C.I., et al. Blood 114(7):1405-1416(2009)Herrera-Galeano, J.E., et al. Arterioscler. Thromb. Vasc. Biol. 28(8):1484-1490(2008)Nanda, N., et al. J. Biol. Chem. 280(26):24680-24689(2005)Nanda, N., et al. J. Biol. Chem. 280(26):24680-24689(2005)
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