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SYT8 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8NBV8 |
|---|---|
| Other Accession | NP_612634.3 |
| Clone Names | 91230240 |
| Gene ID | 90019 |
|---|---|
| Other Names | Synaptotagmin-8, Synaptotagmin VIII, SytVIII, SYT8 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SYT8 |
|---|---|
| Function | Involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca(2+)-regulation of exocytosis in insulin secreted cells. |
| Cellular Location | Cell membrane; Single-pass type III membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9R0N6} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Synaptotagmins, such as SYT8, share a common domainstructure that includes a transmembrane domain and a cytoplasmicregion composed of 2 C2 domains. Some synaptotagmins are involvedin synaptic membrane fusion, while others have a more generalfunction in endocytosis. For further information on synaptotagmins,see MIM 185605.
References
Bailey, S.D., et al. Diabetes Care (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Li, C., et al. Nature 375(6532):594-599(1995)
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