|Other Names||Kelch-like protein 17, Actinfilin, KLHL17|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity).|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=Postsynaptic density.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is expressed in neuronsof most regions of the brain. It contains an N-terminal BTB domain,which mediates dimerization of the protein, and a C-terminal Kelchdomain, which mediates binding to F-actin. This protein may play akey role in the regulation of actin-based neuronal function.
Chen, Y., et al. J. Biol. Chem. 277(34):30495-30501(2002)
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