|Other Names||Leiomodin-2, Cardiac leiomodin, C-LMOD, LMOD2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mediates nucleation of actin filaments and thereby promotes actin polymerization (PubMed:18403713, PubMed:26370058, PubMed:25250574, PubMed:26417072). Plays a role in the regulation of actin filament length (By similarity). Required for normal sarcomere organization in the heart, and for normal heart function (PubMed:18403713).|
|Cellular Location||Cytoplasm, myofibril, sarcomere. Cytoplasm, myofibril. Cytoplasm, myofibril, sarcomere, M line Cytoplasm, cytoskeleton Note=Colocalizes with actin filaments in sarcomeres. Detected close to the M line.|
|Tissue Location||Specifically expressed in heart and skeletal muscles, with higher levels in heart (at protein level). Not expressed in other tissues.|
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Chereau, D., et al. Science 320(5873):239-243(2008)Lane, H.Y., et al. J Clin Psychopharmacol 26(2):128-134(2006)Conley, C.A., et al. Genomics 73(2):127-139(2001)
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