XKR8 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9H6D3 |
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Other Accession | NP_060523.2 |
Clone Names | 91230018 |
Gene ID | 55113 |
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Other Names | XK-related protein 8, hXkr8, XK-related protein 8, processed form, XKR8, XRG8 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | XKR8 {ECO:0000303|PubMed:23845944, ECO:0000312|HGNC:HGNC:25508} |
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Function | [XK-related protein 8, processed form]: Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface (PubMed:23845944, PubMed:25231987). Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment (PubMed:23845944). Required for the clearance of apoptotic cells, such as engulfment of apoptotic germ cells by Sertoli cells, clearance of senescent neutrophils or regulation of bipolar cell numbers in the retina (By similarity). Has no effect on calcium-induced exposure of phosphatidylserine (PubMed:23845944). Promotes myoblast differentiation and survival (PubMed:28881496). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region |
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Provided below are standard protocols that you may find useful for product applications.
References
Gregory, S.G., et al. Nature 441(7091):315-321(2006)
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