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PHF2a/b Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O75151 |
|---|---|
| Other Accession | Q9WTU0 |
| Gene ID | 5253 |
|---|---|
| Other Names | Lysine-specific demethylase PHF2, 11411-, GRC5, PHD finger protein 2, PHF2, CENP-35, KIAA0662 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 1000-1017 of HUMAN PHF2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PHF2 (HGNC:8920) |
|---|---|
| Function | Lysine demethylase that demethylates both histones and non- histone proteins (PubMed:20129925, PubMed:21167174, PubMed:21532585). Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B (PubMed:21532585). Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes (PubMed:21532585). The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (PubMed:21532585). Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (By similarity). |
| Cellular Location | Nucleus, nucleolus. Chromosome, centromere, kinetochore |
| Tissue Location | Widely expressed, including in liver (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure.
References
Hasenpusch-Theil, K., et al., Mamm. Genome 10(3):294-298 (1999).
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