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PHF2a/b Blocking Peptide (C-term)

Synthetic peptide

Product Information
Primary Accession O75151
Other Accession Q9WTU0
Additional Information
Gene ID 5253
Other Names Lysine-specific demethylase PHF2, 11411-, GRC5, PHD finger protein 2, PHF2, CENP-35, KIAA0662
Target/Specificity The synthetic peptide sequence is selected from aa 1000-1017 of HUMAN PHF2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PHF2
Synonyms CENP-35, KIAA0662
Function Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA.
Cellular Location Nucleus, nucleolus. Chromosome, centromere, kinetochore
Tissue Location Widely expressed, including in liver (at protein level).
Research Areas
Citations (0)

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This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure.


Hasenpusch-Theil, K., et al., Mamm. Genome 10(3):294-298 (1999).

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$ 80.00
$ 99.00
Cat# BP1037b
(40 western blots)
Availability: 2 weeks
Bulk Size
Seasonal Special on Bulk Order
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