NEU4 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8WWR8 |
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Other Accession | NP_001161072.1, NP_542779.2, NP_001161074.1, NP_001161071.1, NP_001161073.1 |
Clone Names | 90625142 |
Gene ID | 129807 |
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Other Names | Sialidase-4, N-acetyl-alpha-neuraminidase 4, NEU4 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | NEU4 |
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Function | Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Efficiently hydrolyzes gangliosides including alpha- (2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:15847605, PubMed:21521691, PubMed:15213228). Hydrolyzes poly- alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons (By similarity). May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation (PubMed:21521691). Has sialidase activity toward mucin, fetuin and sialyllactose (PubMed:15847605). |
Cellular Location | [Isoform 1]: Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q8BZL1} Note=Predominantly associates with endoplasmic reticulum membranes Only a small fraction associates with mitochondrial and plasma membranes. |
Tissue Location | [Isoform 1]: Predominant form in liver. Also expressed in brain, kidney and colon. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to a family ofglycohydrolytic enzymes, which remove terminal sialic acid residuesfrom various sialo derivatives, such as glycoproteins, glycolipids,oligosaccharides, and gangliosides. Alternatively splicedtranscript variants encoding different isoforms have been noted forthis gene.
References
Bigi, A., et al. Glycobiology 20(2):148-157(2010)Xin, X., et al. Genome Res. 19(7):1262-1269(2009)Miyagi, T., et al. Proteomics 8(16):3303-3311(2008)Stamatos, N.M., et al. FEBS J. 272(10):2545-2556(2005)Hillier, L.W., et al. Nature 434(7034):724-731(2005)
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