|Other Names||N(G), N(G)-dimethylarginine dimethylaminohydrolase 2, DDAH-2, Dimethylarginine dimethylaminohydrolase 2, DDAHII, Dimethylargininase-2, Protein G6a, S-phase protein, DDAH2, DDAH, G6A, NG30|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DDAH, G6A, NG30|
|Function||Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.|
|Cellular Location||Cytoplasm. Mitochondrion. Note=Translocates from cytosol to mitochondrion upon IL-1beta stimulation in chondrocytes|
|Tissue Location||Detected in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas, and at very low levels in brain.|
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Provided below are standard protocols that you may find useful for product applications.
This gene belongs to the dimethylargininedimethylaminohydrolase (DDAH) gene family. The encoded enzyme playsa role in nitric oxide generation by regulating cellularconcentrations of methylarginines, which in turn inhibit nitricoxide synthase activity.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Caplin, B., et al. Kidney Int. 77(5):459-467(2010)Abhary, S., et al. PLoS ONE 5 (3), E9462 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :
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