|Other Accession||NP_001116224.1, NP_005016.1|
|Other Names||Neuroserpin, Peptidase inhibitor 12, PI-12, Serpin I1, SERPINI1, PI12|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin (PubMed:9442076, PubMed:26329378, PubMed:19265707, PubMed:19285087, PubMed:11880376). May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable).|
|Cellular Location||Secreted. Cytoplasmic vesicle, secretory vesicle lumen. Perikaryon|
|Tissue Location||Detected in brain cortex and hippocampus pyramidal neurons (at protein level) (PubMed:17040209) Predominantly expressed in the brain (PubMed:9070919)|
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This gene encodes a member of the serpin superfamily ofserine proteinase inhibitors. The protein is primarily secreted byaxons in the brain, and preferentially reacts with and inhibitstissue-type plasminogen activator. It is thought to play a role inthe regulation of axonal growth and the development of synapticplasticity. Mutations in this gene result in familialencephalopathy with neuroserpin inclusion bodies (FENIB), which isa dominantly inherited form of familial encephalopathy and epilepsycharacterized by the accumulation of mutant neuroserpin polymers.Multiple alternatively spliced variants, encoding the same protein,have been identified.
Takehara, S., et al. J. Mol. Biol. 403(5):751-762(2010)Han, S., et al. Hum. Immunol. 71(7):727-730(2010)Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)Davies, M.J., et al. J. Biol. Chem. 284(27):18202-18209(2009)Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 18(5):1651-1658(2009)
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