|Other Accession||NP_112509.3, NP_112508.3|
|Other Names||N-terminal EF-hand calcium-binding protein 3, Amyloid beta A4 protein-binding family A member 2-binding protein, Nek2-interacting protein 1, Neuronal calcium-binding protein 3, X11L-binding protein 51, NECAB3, APBA2BP, NIP1, SYTIP2, XB51|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||APBA2BP, NIP1, SYTIP2, XB51|
|Function||Inhibits the interaction of APBA2 with beta-amyloid precursor protein (APP), and hence allows formation of beta- amyloid.|
|Cellular Location||Golgi apparatus|
|Tissue Location||Strongly expressed in heart and skeletal muscle, moderately in brain and pancreas|
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The protein encoded by this gene interacts with theamino-terminal domain of the neuron-specific X11-like protein(X11L), inhibits the association of X11L with amyloid precursorprotein through a non-competitive mechanism, and abolishes thesuppression of beta-amyloid production by X11L. This protein,together with X11L, may play an important role in the regulatorysystem of amyloid precursor protein metabolism and beta-amyloidgeneration. The protein is phosphorylated by NIMA-related expressedkinase 2, and localizes to the Golgi apparatus. Multiple transcriptvariants encoding different isoforms have been found for this gene.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Kim, H.T., et al. Dev. Dyn. 237(12):3921-3926(2008)Yoo, J.C., et al. Exp. Cell Res. 292(2):393-402(2004)Sumioka, A., et al. Biochem. J. 374 (PT 1), 261-268 (2003) :Sugita, S., et al. Neuroscience 112(1):51-63(2002)
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