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GAL3ST2 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H3Q3 |
|---|---|
| Other Accession | NP_071417.2 |
| Clone Names | 91102297 |
| Gene ID | 64090 |
|---|---|
| Other Names | Galactose-3-O-sulfotransferase 2, Gal3ST-2, 282-, Beta-galactose-3-O-sulfotransferase 2, Gal-beta-1, 3-GalNAc 3'-sulfotransferase 2, Glycoprotein beta-Gal 3'-sulfotransferase 2, GAL3ST2, GP3ST |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GAL3ST2 |
|---|---|
| Synonyms | GP3ST |
| Function | Transfers a sulfate group to the hydroxyl group at C3 of non- reducing beta-galactosyl residues. Acts both on type 1 (Gal-beta-1,3- GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency. |
| Cellular Location | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein |
| Tissue Location | Ubiquitous. Detected in heart, stomach, colon, liver and spleen, in epithelial cells lining the lower to middle layer of the crypts in colonic mucosa, hepatocytes surrounding the central vein of the liver, extravillous cytotrophoblasts in the basal plate of the septum of the placenta, renal tubules of the kidney, and neuronal cells of the cerebral cortex. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of thegalactose-3-O-sulfotransferase protein family. The product of thisgene catalyzes sulfonation by transferring a sulfate group to thehydroxyl at C-3 of nonreducing beta-galactosyl residues, and it canact on both type 1 and type 2 (Galbeta 1-3/1-4GlcNAc-R)oligosaccharides with similar efficiencies, and on core 1 glycans.This enzyme has been implicated in tumor metastasis processes. Thisgene is different from the GAL3ST3 gene located on chromosome 11,which has also been referred to as GAL3ST2 and encodes a relatedenzyme with distinct tissue distribution and substratespecificities, compared to galactose-3-O-sulfotransferase 2.
References
Seko, A., et al. Biochem. J. 391 (PT 1), 77-85 (2005) :Shi, B.Z., et al. Biochem. Biophys. Res. Commun. 332(4):934-940(2005)Chandrasekaran, E.V., et al. J. Biol. Chem. 279(11):10032-10041(2004)Seko, A., et al. Jpn. J. Cancer Res. 93(5):507-515(2002)Koma, M., et al. J. Biochem. 131(4):517-522(2002)
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