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LCOR Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96JN0 |
|---|---|
| Other Accession | NP_115816.2, NP_001164237.1, NP_001164236.1 |
| Clone Names | 91109217 |
| Gene ID | 84458 |
|---|---|
| Other Names | Ligand-dependent corepressor, LCoR, Mblk1-related protein 2, LCOR, KIAA1795, MLR2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | LCOR (HGNC:29503) |
|---|---|
| Function | May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320, ECO:0000269|PubMed:12535528} |
| Tissue Location | Ubiquitous.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
LCOR is a transcriptional corepressor widely expressed infetal and adult tissues that is recruited to agonist-bound nuclearreceptors through a single LxxLL motif, also referred to as anuclear receptor (NR) box (Fernandes et al., 2003 [PubMed12535528]).
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Palijan, A., et al. J. Biol. Chem. 284(44):30275-30287(2009)Palijan, A., et al. J. Biol. Chem. 284(44):30264-30274(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Deloukas, P., et al. Nature 429(6990):375-381(2004)
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