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Dnmt3L Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9UJW3
Clone Names 2080812
Peptide ID 2080812
Additional Information
Gene ID 29947
Other Names DNA (cytosine-5)-methyltransferase 3-like, DNMT3L
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1040a was selected from the C-term region of human Dnmt3L. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3.
Cellular Location Nucleus.
Tissue Location Expressed at low levels in several tissues including testis, ovary, and thymus
Research Areas
Citations (0)

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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases. This protein is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, this protein does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and it is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternative splicing results in two transcript variants. An additional splice variant has been described but its biological validity has not been determined.


Chedin, F., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16916-16921 (2002).Kierszenbaum, A.L., Mol. Reprod. Dev. 63(3):269-272 (2002).Deplus, R., et al., Nucleic Acids Res. 30(17):3831-3838 (2002).Hata, K., et al., Development 129(8):1983-1993 (2002).Burgers, W.A., et al., Trends Genet. 18(6):275-277 (2002).

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$ 80.00
Cat# BP1040a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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