|Other Names||Synaptonemal complex central element protein 2, Central element synaptonemal complex protein 1, SYCE2, CESC1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination (By similarity).|
|Cellular Location||Nucleus. Note=Associates with chromatin. In prophase I stage of meiosis, localizes in the transverse central elements of the central region between lateral elements of the synaptonemal complexes. Found only where the chromosome cores are synapsed. Colocalizes with SYCE1 in the central elements (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Bolcun-Filas, E., et al. J. Cell Biol. 176(6):741-747(2007)Costa, Y., et al. J. Cell. Sci. 118 (PT 12), 2755-2762 (2005) :Grimwood, J., et al. Nature 428(6982):529-535(2004)
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