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27Kip1-T157 Antibody Blocking peptide

Synthetic peptide

Product Information
Primary Accession P46527
Other Accession NP_004055.1
Clone Names 4110562
Peptide ID 4110562
Additional Information
Gene ID 1027
Other Names Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, p27Kip1, CDKN1B, KIP1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIP1
Function Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1- CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
Cellular Location Nucleus. Cytoplasm. Endosome. Note=Nuclear and cytoplasmic in quiescent cells. AKT- or RSK- mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen- activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89 Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (By similarity).
Tissue Location Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney
Research Areas
Citations (0)

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This gene encodes a cyclin-dependent kinase inhibitor,which shares a limited similarity with CDK inhibitor CDKN1A/p21.The encoded protein binds to and prevents the activation of cyclinE-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycleprogression at G1. The degradation of this protein, which istriggered by its CDK dependent phosphorylation and subsequentubiquitination by SCF complexes, is required for the cellulartransition from quiescence to the proliferative state. [provided byRefSeq].


Kajihara, R., et al. Biochem. Biophys. Res. Commun. 401(3):350-355(2010)Kedde, M., et al. Nat. Cell Biol. 12(10):1014-1020(2010)Canbay, E., et al. Anticancer Res. 30(7):3093-3098(2010)Do Nascimento Borges, B., et al. In Vivo 24(4):579-582(2010)Qin, J., et al. Hepatogastroenterology 57 (99-100), 547-553 (2010) :

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$ 80.00
Cat# BP10418a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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