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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   Cofilin (Ser3) antibody Blocking peptide   

Cofilin (Ser3) antibody Blocking peptide

Synthetic peptide

     
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  • CITATIONS
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Product Information
Primary Accession P23528
Other Accession NP_005498.1
Clone Names 100720004
Peptide ID 100720004
Additional Information
Gene ID 1072
Other Names Cofilin-1, 18 kDa phosphoprotein, p18, Cofilin, non-muscle isoform, CFL1, CFL
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CFL1
Synonyms CFL
Function Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:11812157, PubMed:15580268, PubMed:21834987, PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity).
Cellular Location Nucleus matrix. Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide
Tissue Location Widely distributed in various tissues.
Research Areas
Citations (0)

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Background

Cofilin is a widely distributed intracellularactin-modulating protein that binds and depolymerizes filamentousF-actin and inhibits the polymerization of monomeric G-actin in apH-dependent manner. It is involved in the translocation ofactin-cofilin complex from cytoplasm to nucleus.

References

Klemke, M., et al. EMBO J. 29(17):2915-2929(2010)Castro, M.A., et al. Cancer 116(15):3645-3655(2010)Garg, P., et al. J. Biol. Chem. 285(29):22676-22688(2010)Martins-de-Souza, D., et al. J Psychiatr Res (2010) In press :Zhang, Y., et al. J. Int. Med. Res. 38(3):1042-1048(2010)

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$ 80.00
Cat# BP10431a
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