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SCXA Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q7RTU7
Other Accession NP_001073983.1, NP_001008272.1
Clone Names 91216112
Peptide ID 91216112
Additional Information
Other Names Basic helix-loop-helix transcription factor scleraxis, Class A basic helix-loop-helix protein 41, bHLHa41, Class A basic helix-loop-helix protein 48, bHLHa48, SCX, BHLHA41, BHLHA48, SCXA, SCXB
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SCX
Function Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981} EMBL; AC145291; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BK000280; DAA00239.1; -; Genomic_DNA CCDS; CCDS43779.1; - RefSeq; NP_001073983.1; NM_001080514.2 RefSeq; XP_006716679.1; XM_006716616.2 UniGene; Hs.553250; - UniGene; Hs.723088; - ProteinModelPortal; Q7RTU7; - SMR; Q7RTU7; - BioGrid; 568157; 3 IntAct; Q7RTU7; 3 STRING; 9606.ENSP00000345599; - iPTMnet; Q7RTU7; - PhosphoSitePlus; Q7RTU7; - DMDM; 74749943; - PaxDb; Q7RTU7; - PeptideAtlas; Q7RTU7; - PRIDE; Q7RTU7; - ProteomicsDB; 68909; - Ensembl; ENST00000567180; ENSP00000476384; ENSG00000260428 GeneID; 642658; - KEGG; hsa:642658; - UCSC; uc003zbn.4; human CTD; 642658; - EuPathDB; HostDB:ENSG00000260428.2; - GeneCards; SCX; - HGNC; HGNC:32322; SCX HPA; HPA043183; - MIM; 609067; gene neXtProt; NX_Q7RTU7; - OpenTargets; ENSG00000260428; - PharmGKB; PA142670943; - eggNOG; KOG4029; Eukaryota eggNOG; ENOG411227D; LUCA GeneTree; ENSGT00760000119097; - HOGENOM; HOG000231706; - HOVERGEN; HBG036149; - InParanoid; Q7RTU7; - OMA; GQPCHTT; - OrthoDB; EOG091G0RR2; - PhylomeDB; Q7RTU7; - TreeFam; TF315153; - GeneWiki; LOC642658; - GenomeRNAi; 642658; - PRO; PR:Q7RTU7; - Proteomes; UP000005640; Chromosome 8 Bgee; ENSG00000260428; - CleanEx; HS_SCXA; - GO; GO:0005634; C:nucleus; IDA:UniProtKB GO; GO:0005667; C:transcription factor complex; IDA:UniProtKB GO; GO:0043425; F:bHLH transcription factor binding; IPI:UniProtKB GO; GO:0003677; F:DNA binding; ISS:UniProtKB GO; GO:0070888; F:E-box binding; IEA:Ensembl GO; GO:0046982; F:protein heterodimerization activity; IDA:UniProtKB GO; GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IEA:Ensembl GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISA:NTNU_SB GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB GO; GO:0001205; F:transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding; IEA:Ensembl GO; GO:0030509; P:BMP signaling pathway; ISS:UniProtKB GO; GO:0030154; P:cell differentiation; ISS:UniProtKB GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Ensembl GO; GO:0002062; P:chondrocyte differentiation; ISS:UniProtKB GO; GO:0030199; P:collagen fibril organization; ISS:UniProtKB GO; GO:0035993; P:deltoid tuberosity development; ISS:UniProtKB GO; GO:0048706; P:embryonic skeletal system development; IEA:Ensembl GO; GO:0001958; P:endochondral ossification; ISS:UniProtKB GO; GO:0060325; P:face morphogenesis; IEA:Ensembl GO; GO:0003188; P:heart valve formation; ISS:UniProtKB GO; GO:0003179; P:heart valve morphogenesis; ISS:UniProtKB GO; GO:0001707; P:mesoderm formation; ISS:UniProtKB GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl GO; GO:0061036; P:positive regulation of cartilage development; ISS:UniProtKB GO; GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB GO; GO:0032967; P:positive regulation of collagen biosynthetic process; ISS:UniProtKB GO; GO:2000543; P:positive regulation of gastrulation; ISS:UniProtKB GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB GO; GO:0061035; P:regulation of cartilage development; ISS:UniProtKB GO; GO:0061056; P:sclerotome development; IEA:Ensembl GO; GO:0060008; P:Sertoli cell differentiation; ISS:UniProtKB GO; GO:0035914; P:skeletal muscle cell differentiation; IEA:Ensembl GO; GO:0035990; P:tendon cell differentiation; ISS:UniProtKB GO; GO:0035989; P:tendon development; ISS:UniProtKB GO; GO:0035992; P:tendon formation; ISS:UniProtKB GO; GO:0001894; P:tissue homeostasis; ISS:UniProtKB GO; GO:0006351; P:transcription, DNA-templated; IDA:UniProtKB CDD; cd00083; HLH; 1 Gene3D;; -; 1 InterPro; IPR011598; bHLH_dom InterPro; IPR036638; HLH_DNA-bd_sf Pfam; PF00010; HLH; 1 SMART; SM00353; HLH; 1 SUPFAM; SSF47459; SSF47459; 1 PROSITE; PS50888; BHLH; 1 3: Inferred from homology; Activator; Complete proteome; Developmental protein; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation CHAIN 1 201 Basic helix-loop-helix transcription factor scleraxis /FTId=PRO_0000273317 DOMAIN 75 127 bHLH. {ECO:0000255|PROSITE- ProRule:PRU00981} COMPBIAS 158 166 Poly-Pro SEQUENCE 201 AA; 21596 MW; 4FDF2D23F977032A CRC64; MSFATLRPAP PGRYLYPEVS PLSEDEDRGS DSSGSDEKPC RVHAARCGLQ GARRRAGGRR AGGGGPGGRP GREPRQRHTA NARERDRTNS VNTAFTALRT LIPTEPADRK LSKIETLRLA SSYISHLGNV LLAGEACGDG QPCHSGPAFF HAARAGSPPP PPPPPPARDG ENTQPKQICT FCLSNQRKLS KDRDRKTAIR S
Research Areas
Citations (0)

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Furumatsu, T., et al. Int. J. Biochem. Cell Biol. 42(1):148-156(2010)Liu, Q., et al. Zhonghua Kou Qiang Yi Xue Za Zhi 41(9):556-558(2006)Nusbaum, C., et al. Nature 439(7074):331-335(2006)Schulze-Tanzil, G., et al. Histochem. Cell Biol. 122(3):219-228(2004)Salingcarnboriboon, R., et al. Exp. Cell Res. 287(2):289-300(2003)

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Cat# BP10439b
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