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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   ENSA Antibody (Center) Blocking Peptide   

ENSA Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O43768
Other Accession NP_996927.1, NP_996929.1, NP_996925.1, NP_004427.1, NP_996930.1, NP_997051.1, NP_996926.1, N
Clone Names 81006126
Peptide ID 81006126
Additional Information
Gene ID 2029
Other Names Alpha-endosulfine, ARPP-19e, ENSA
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.
Cellular Location Cytoplasm.
Tissue Location Widely expressed with high levels in skeletal muscle and brain and lower levels in the pancreas
Research Areas
Citations (0)

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ENSA belongs to a highlyconserved cAMP-regulated phosphoprotein (ARPP) family. This proteinwas identified as an endogenous ligand for the sulfonylureareceptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of theATP-sensitive potassium (KATP) channel, which is located on theplasma membrane of pancreatic beta cells and plays a key role inthe control of insulin release from pancreatic beta cells. Thisprotein is thought to be an endogenous regulator of KATP channels.In vitro studies have demonstrated that this protein modulatesinsulin secretion through the interaction with KATP channel, andthis gene has been proposed as a candidate gene for type 2diabetes.


Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Gabrielsson, B.G., et al. Mol. Cell. Biochem. 258 (1-2), 65-71 (2004) :Thameem, F., et al. Mol. Genet. Metab. 81(1):16-21(2004)

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$ 80.00
Cat# BP10456c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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Ordering Information

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