|Other Names||Carbohydrate sulfotransferase 3, Chondroitin 6-O-sulfotransferase 1, C6ST-1, Chondroitin 6-sulfotransferase, Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0, GST-0, CHST3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N- acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Widely expressed in adult tissues. Expressed in heart, placenta, skeletal muscle and pancreas. Also expressed in various immune tissues such as spleen, lymph node, thymus and appendix.|
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Provided below are standard protocols that you may find useful for product applications.
CHST3 is an enzyme which catalyzes the sulfationof chondroitin, a proteoglycan found in the extracellular matrixand most cells which is involved in cell migration anddifferentiation.
Unger, S., et al. Am. J. Med. Genet. A 152A (10), 2543-2549 (2010) :Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)Tuysuz, B., et al. Clin. Genet. 75(4):375-383(2009)Kitagawa, H., et al. J. Biol. Chem. 283(41):27438-27443(2008)Hermanns, P., et al. Am. J. Hum. Genet. 82(6):1368-1374(2008)
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