|Other Names||Collagen alpha-1(XIX) chain, Collagen alpha-1(Y) chain, COL19A1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Localized to vascular, neuronal, mesenchymal, and some epithelial basement membrane zones in umbilical cord|
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Provided below are standard protocols that you may find useful for product applications.
COL19A1 encodes the alpha chain of type XIX collagen, amember of the FACIT collagen family (fibril-associated collagenswith interrupted helices). Although the function of this collagenis not known, other members of this collagen family are found inassociation with fibril-forming collagens such as type I and II,and serve to maintain the integrity of the extracellular matrix.The transcript produced from this gene has an unusually large 3'UTR which has not been completely sequenced.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Barber, M.J., et al. PLoS ONE 5 (3), E9763 (2010) :Boudko, S.P., et al. J. Biol. Chem. 283(49):34345-34351(2008)Kapyla, J., et al. J. Biol. Chem. 279(49):51677-51687(2004)Mungall, A.J., et al. Nature 425(6960):805-811(2003)
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