|Other Accession||NP_001161066.1, NP_000299.2, NP_001121167.1|
|Other Names||Lysosomal protective protein, Carboxypeptidase C, Carboxypeptidase L, Cathepsin A, Protective protein cathepsin A, PPCA, Protective protein for beta-galactosidase, Lysosomal protective protein 32 kDa chain, Lysosomal protective protein 20 kDa chain, CTSA, PPGB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.|
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Provided below are standard protocols that you may find useful for product applications.
CTSA encodes a glycoprotein which associates withlysosomal enzymes beta-galactosidase and neuraminidase to form acomplex of high molecular weight multimers. The formation of thiscomplex provides a protective role for stability and activity.Deficiencies in this gene are linked to multiple forms ofgalactosialidosis.
Reich, M., et al. Immunol. Lett. 128(2):143-147(2010)Bonten, E.J., et al. J. Biol. Chem. 284(41):28430-28441(2009)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Tatano, Y., et al. J. Med. Invest. 53 (1-2), 103-112 (2006) :Lewandrowski, U., et al. Mol. Cell Proteomics 5(2):226-233(2006)
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