|Other Accession||NP_954674.1, NP_001135742.1, NP_001135743.1, NP_005762.2|
|Other Names||Dehydrogenase/reductase SDR family member 9, 11--, 3-alpha hydroxysteroid dehydrogenase, 3-alpha-HSD, NADP-dependent retinol dehydrogenase/reductase, RDH-E2, RDHL, Short-chain dehydrogenase/reductase retSDR8, Tracheobronchial epithelial cell-specific retinol dehydrogenase, RDH-TBE, DHRS9|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||3-alpha-hydroxysteroid dehydrogenase that converts 3- alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH.|
|Cellular Location||Microsome membrane. Endoplasmic reticulum membrane. Note=Associated with microsomal membranes|
|Tissue Location||Highly expressed in trachea and epidermis. Detected at lower levels in spinal cord, bone marrow, brain, tongue, esophagus, heart, colon, testis, placenta, lung, skeletal muscle and lymph node.|
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3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. It may play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH.
Persson, B., et al. Chem. Biol. Interact. 178 (1-3), 94-98 (2009) :Jones, R.J., et al. J. Biol. Chem. 282(11):8317-8324(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Jette, C., et al. J. Biol. Chem. 279(33):34397-34405(2004)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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