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CCR8 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P51685 |
|---|---|
| Other Accession | NP_005192.1 |
| Clone Names | 91019020 |
| Gene ID | 1237 |
|---|---|
| Other Names | C-C chemokine receptor type 8, C-C CKR-8, CC-CKR-8, CCR-8, CC chemokine receptor CHEMR1, CMKBRL2, Chemokine receptor-like 1, CKR-L1, GPR-CY6, GPRCY6, TER1, CDw198, CCR8, CKRL1, CMKBR8, CMKBRL2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CCR8 |
|---|---|
| Synonyms | CKRL1, CMKBR8, CMKBRL2 |
| Function | Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CCR8 encodes a member of the beta chemokine receptorfamily, which is predicted to be a seven transmembrane proteinsimilar to G protein-coupled receptors. Chemokines and theirreceptors are important for the migration of various cell typesinto the inflammatory sites. This receptor protein preferentiallyexpresses in the thymus. I-309, thymus activation-regulatedcytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1beta) have been identified as ligands of this receptor. Studies ofthis receptor and its ligands suggested its role in regulation ofmonocyte chemotaxis and thymic cell apoptosis. More specifically,this receptor may contribute to the proper positioning of activatedT cells within the antigenic challenge sites and specialized areasof lymphoid tissues. CCR8 is located at the chemokine receptorgene cluster region.
References
Mutalithas, K., et al. Clin. Exp. Allergy 40(8):1175-1185(2010)Han, S., et al. Hum. Immunol. 71(7):727-730(2010)Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 18(5):1651-1658(2009)
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