|Other Names||Type II inositol 1, 5-trisphosphate 5-phosphatase, 75 kDa inositol polyphosphate-5-phosphatase, Phosphoinositide 5-phosphatase, 5PTase, INPP5B, OCRL2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.|
|Cellular Location||Cytoplasm, cytosol. Endoplasmic reticulum- Golgi intermediate compartment. Early endosome membrane. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, phagosome membrane. Golgi apparatus|
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Provided below are standard protocols that you may find useful for product applications.
Cellular calcium signaling is controlled by the productionof inositol phosphates (IPs) by phospholipase C in response toextracellular signals. The IP signaling molecules are inactivatedby a family of inositol polyphosphate-5-phosphatases(5-phosphatases). INPP5B encodes the type II 5-phosphatase. Theprotein is localized to the cytosol and mitochondria, andassociates with membranes through an isoprenyl modification nearthe C-terminus. Several alternatively spliced transcript variantsof this gene have been described, but the full-length nature ofsome of these variants has not been determined. [provided byRefSeq].
Coon, B.G., et al. Hum. Mol. Genet. 18(23):4478-4491(2009)Mao, Y., et al. EMBO J. 28(13):1831-1842(2009)Williams, C., et al. J. Cell. Sci. 120 (PT 22), 3941-3951 (2007) :Speed, C.J., et al. Eur. J. Biochem. 234(1):216-224(1995)Janne, P.A., et al. Genomics 28(2):280-285(1995)
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