|Other Names||Integrin alpha-E, HML-1 antigen, Integrin alpha-IEL, Mucosal lymphocyte 1 antigen, CD103, Integrin alpha-E light chain, Integrin alpha-E heavy chain, ITGAE|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells|
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Integrins are heterodimeric integral membrane proteinscomposed of an alpha chain and a beta chain. ITGAE encodes anI-domain-containing alpha integrin that undergoespost-translational cleavage in the extracellular domain, yieldingdisulfide-linked heavy and light chains. In combination with thebeta 7 integrin, this protein forms the E-cadherin binding integrinknown as the human mucosal lymphocyte-1 antigen. This protein ispreferentially expressed in human intestinal intraepitheliallymphocytes (IEL), and in addition to a role in adhesion, it mayserve as an accessory molecule for IEL activation. [provided byRefSeq].
Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)Liu, Y.H., et al. Ophthalmology 117(8):1645-1651(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Davila, S., et al. Genes Immun. 11(3):232-238(2010)Heron, M., et al. Clin. Immunol. 133(1):117-125(2009)
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