|Other Accession||NP_543020.2, NP_570612.1|
|Other Names||Cystatin-11, CST11, CST8L|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization.|
|Cellular Location||Secreted. Note=Probably secreted into the epididymis lumen, where it localizes to the outer surface of sperm. Specifically localizes to the postacrosomal and tail regions of sperm|
|Tissue Location||Detected in the epithelium and lumen of the epididymis, and in sperm (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
The cystatin superfamily encompasses proteins that containmultiple cystatin-like sequences. Some of the members are activecysteine protease inhibitors, while others have lost or perhapsnever acquired this inhibitory activity. There are three inhibitoryfamilies in the superfamily, including the type 1 cystatins(stefins), type 2 cystatins and the kininogens. The type 2 cystatinproteins are a class of cysteine proteinase inhibitors found in avariety of human fluids and secretions. The cystatin locus onchromosome 20 contains the majority of the type 2 cystatin genesand pseudogenes. CST11 is located in the cystatin locus andencodes an epididymal-specific protein whose specific function hasnot been determined. Alternative splicing yields two variantsencoding distinct isoforms.
Hamil, K.G., et al. Endocrinology 143(7):2787-2796(2002)Deloukas, P., et al. Nature 414(6866):865-871(2001)Brown, W.M., et al. Protein Sci. 6(1):5-12(1997)Dickinson, D.P., et al. Genomics 24(1):172-175(1994)Thiesse, M., et al. DNA Cell Biol. 13(2):97-116(1994)
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