|Other Names||Protein CASC4, Cancer susceptibility candidate gene 4 protein, CASC4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
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The increased expression level of this gene is associatedwith HER-2/neu proto-oncogene overexpression. Amplification andresulting overexpression of this proto-oncogene are found inapproximately 30% of human breast and 20% of human ovarian cancers.Further characterization of the product of this gene may yieldinsight into the fundamental biology and pathogenetic effects ofHER-2/neu overexpression in human breast and ovarian cancer cells.Alternatively spliced variants encoding different isoforms havebeen identified for this gene.
Lamesch, P., et al. Genomics 89(3):307-315(2007)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)Sato, T., et al. Onkologie 26(3):268-271(2003)Scheer, M., et al. Mund Kiefer Gesichtschir 7(3):138-145(2003)Oh, J.J., et al. Nucleic Acids Res. 27(20):4008-4017(1999)
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