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Me2-H3(K9) Antibody Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q6NXT2
Clone Names 2032212
Peptide ID 2032212
Additional Information
Gene ID 440093
Other Names Histone H33C, Histone H35, H3F3C
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1051b was selected from the 2Me region of human Methyl-H3-mK9(2Me). A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name H3F3C
Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes.
Cellular Location Nucleus. Chromosome.
Tissue Location Specifically expressed in the seminiferous tubules of testis.
Research Areas
Citations (0)

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Background

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. This protein is a core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

References

Scherer,S.E., Nature 440 (7082), 346-351 (2006)

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$ 80.00
Cat# BP1051b
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