|Other Accession||NP_892017.2, NP_001070865.1|
|Other Names||Interferon regulatory factor 2-binding protein 2, IRF-2-binding protein 2, IRF-2BP2, IRF2BP2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a transcriptional corepressor in a IRF2- dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle.|
|Cellular Location||Cytoplasm. Nucleus.|
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IRF2BP2 encodes an interferon regulatory factor-2 (IRF2)binding protein that interacts with the C-terminal transcriptionalrepression domain of IRF2. Alternative splicing results in multipletranscript variants encoding distinct isoforms. [provided byRefSeq].
Teng, A.C., et al. FASEB J. (2010) In press :Peng, Y.B., et al. Anim. Genet. 37(6):600-601(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
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