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CLEC10A Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8IUN9 |
|---|---|
| Other Accession | NP_878910.1, NP_006335.2 |
| Clone Names | 91230197 |
| Gene ID | 10462 |
|---|---|
| Other Names | C-type lectin domain family 10 member A, C-type lectin superfamily member 14, Macrophage lectin 2, CD301, CLEC10A, CLECSF13, CLECSF14, HML |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CLEC10A |
|---|---|
| Synonyms | CLECSF13, CLECSF14, HML |
| Function | Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells. |
| Cellular Location | Membrane; Single-pass type II membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
CLEC10A encodes a member of the C-type lectin/C-typelectin-like domain (CTL/CTLD) superfamily. Members of this familyshare a common protein fold and have diverse functions, such ascell adhesion, cell-cell signalling, glycoprotein turnover, androles in inflammation and immune response. The encoded type 2transmembrane protein may function as a cell surface antigen. Twotranscript variants encoding distinct isoforms have been identifiedfor this gene.
References
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Iijima, M., et al. Neurology 73(17):1348-1352(2009)van Vliet, S.J., et al. PLoS Pathog. 5 (10), E1000625 (2009) :Suzuki, N., et al. J. Immunol. 156(1):128-135(1996)
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