|Other Accession||NP_878910.1, NP_006335.2|
|Other Names||C-type lectin domain family 10 member A, C-type lectin superfamily member 14, Macrophage lectin 2, CD301, CLEC10A, CLECSF13, CLECSF14, HML|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CLECSF13, CLECSF14, HML|
|Function||Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
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CLEC10A encodes a member of the C-type lectin/C-typelectin-like domain (CTL/CTLD) superfamily. Members of this familyshare a common protein fold and have diverse functions, such ascell adhesion, cell-cell signalling, glycoprotein turnover, androles in inflammation and immune response. The encoded type 2transmembrane protein may function as a cell surface antigen. Twotranscript variants encoding distinct isoforms have been identifiedfor this gene.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Iijima, M., et al. Neurology 73(17):1348-1352(2009)van Vliet, S.J., et al. PLoS Pathog. 5 (10), E1000625 (2009) :Suzuki, N., et al. J. Immunol. 156(1):128-135(1996)
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