LRRC25 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8N386 |
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Other Accession | NP_660299.2 |
Clone Names | 91230250 |
Gene ID | 126364 |
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Other Names | Leucine-rich repeat-containing protein 25, Monocyte and plasmacytoid-activated protein, LRRC25, MAPA |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | LRRC25 |
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Synonyms | MAPA |
Function | Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting RIGI for autophagic degradation. Interacts specifically with ISG15-associated RIGI to promote interaction between RIGI and the autophagic cargo receptor p62/SQSTM1 to mediate RIGI degradation via selective autophagy (PubMed:29288164). Also plays a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA. |
Cellular Location | Membrane; Single-pass type I membrane protein. Cytoplasm |
Tissue Location | Expressed in plasmacytoid dendritic cells (PDC), monocyte-derived dendritic cells (MDDC), granulocytes, monocytes, B- lymphocytes, peripheral blood leukocytes, spleen, bone marrow, and, to a lesser extent, lymph nodes, fetal liver, and appendix but not in thymus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
May be involved in the activation of cells of innate and acquired immunity.
References
Lamesch, P., et al. Genomics 89(3):307-315(2007)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)Rissoan, M.C., et al. Blood 100(9):3295-3303(2002)
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