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KIAA1530 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q2YD98 |
|---|---|
| Other Accession | NP_065945.2 |
| Clone Names | 100111073 |
| Gene ID | 57654 |
|---|---|
| Other Names | UV-stimulated scaffold protein A, UVSSA, KIAA1530 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | UVSSA |
|---|---|
| Synonyms | KIAA1530 |
| Function | Factor involved in transcription-coupled nucleotide excision repair (TC-NER), a mechanism that rapidly removes RNA polymerase II- blocking lesions from the transcribed strand of active genes (PubMed:22466610, PubMed:22466611, PubMed:22466612). Facilitates the ubiquitination of the elongating form of RNA polymerase II (RNA pol IIo) at DNA damage sites, thereby promoting RNA pol IIo backtracking and access by the TC-NER machinery to lesion sites (PubMed:22466611, PubMed:32142649). Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome (PubMed:22466611, PubMed:22466612). Also facilitates transfer of TFIIH to RNA polymerase II (PubMed:32142649). Not involved in processing oxidative damage (PubMed:22466612). |
| Cellular Location | Chromosome. Note=Accumulates at UV DNA damage sites |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Lamesch, P., et al. Genomics 89(3):307-315(2007)
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$ 277.78
Cat# BP10583a
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