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C9orf126 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8N9R8 |
|---|---|
| Other Accession | NP_001138349.1, NP_775961.2 |
| Clone Names | 100111150 |
| Gene ID | 286205 |
|---|---|
| Other Names | Protein SCAI, Suppressor of cancer cell invasion protein, SCAI, C9orf126 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SCAI |
|---|---|
| Synonyms | C9orf126 |
| Function | Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1. |
| Cellular Location | Membrane; Single-pass membrane protein. Nucleus. Cytoplasm. Note=Nuclear localization is required for inhibition of MRTFA. |
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Provided below are standard protocols that you may find useful for product applications.
Background
SCAI encodes a regulator of cell migration. Theencoded protein appears to function in the RhoA (ras homolog genefamily, member A)-Dia1 (diaphanous homolog 1) signal transductionpathway. Alternatively spliced transcript variants have beendescribed.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Brandt, D.T., et al. Nat. Cell Biol. 11(5):557-568(2009)
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