|Other Accession||NP_001138349.1, NP_775961.2|
|Other Names||Protein SCAI, Suppressor of cancer cell invasion protein, SCAI, C9orf126|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Tumor suppressor which functions to suppress MKL1- induced SRF transcriptional activity. May function in the RHOA- DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1.|
|Cellular Location||Membrane; Single-pass membrane protein. Nucleus Cytoplasm. Note=Nuclear localization is required for inhibition of MKL1.|
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SCAI encodes a regulator of cell migration. Theencoded protein appears to function in the RhoA (ras homolog genefamily, member A)-Dia1 (diaphanous homolog 1) signal transductionpathway. Alternatively spliced transcript variants have beendescribed.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Brandt, D.T., et al. Nat. Cell Biol. 11(5):557-568(2009)
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