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C12orf66 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96MD2 |
|---|---|
| Other Accession | NP_689653.3 |
| Clone Names | 100111238 |
| Gene ID | 144577 |
|---|---|
| Other Names | UPF0536 protein C12orf66, C12orf66 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | KICS2 (HGNC:26517) |
|---|---|
| Synonyms | C12orf66 |
| Function | As part of the KICSTOR complex functions in the amino acid- sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. |
| Cellular Location | Lysosome membrane. |
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Provided below are standard protocols that you may find useful for product applications.
References
Xu, X.R., et al. Proc. Natl. Acad. Sci. U.S.A. 98(26):15089-15094(2001)
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