LACE1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8WV93 |
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Other Accession | NP_660358.2 |
Clone Names | 100111270 |
Gene ID | 246269 |
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Other Names | Lactation elevated protein 1, Protein AFG1 homolog, LACE1, AFG1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | AFG1L (HGNC:16411) |
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Function | Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain (PubMed:26759378, PubMed:27323408). Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress (PubMed:27323408). |
Cellular Location | Mitochondrion membrane |
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Provided below are standard protocols that you may find useful for product applications.
Background
LACE1 encodes a protein with possible ATPase function.The protein contains a P-loop motif and a five-domain structurethat is conserved in fly, yeast, and bacteria. Two conservedestrogen receptor binding sites are located within 2.5 kb of thisgene.
References
Bailey, S.D., et al. Diabetes Care (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Mattar, R., et al. Clin. Biochem. 41 (7-8), 628-630 (2008) :Abrahams, B.S., et al. Genomics 80(1):45-53(2002)
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