|Other Names||Lactation elevated protein 1, Protein AFG1 homolog, LACE1, AFG1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain (PubMed:26759378, PubMed:27323408). Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress (PubMed:27323408).|
|Cellular Location||Mitochondrion membrane|
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Provided below are standard protocols that you may find useful for product applications.
LACE1 encodes a protein with possible ATPase function.The protein contains a P-loop motif and a five-domain structurethat is conserved in fly, yeast, and bacteria. Two conservedestrogen receptor binding sites are located within 2.5 kb of thisgene.
Bailey, S.D., et al. Diabetes Care (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Mattar, R., et al. Clin. Biochem. 41 (7-8), 628-630 (2008) :Abrahams, B.S., et al. Genomics 80(1):45-53(2002)
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